Appetite suppressants control hunger – which can be the key to weight loss for many. No matter how hard you exercise, if you don’t properly control your energy intake, you’ll find it tough to reach your fat loss targets.
Weight loss drugs, pills and supplements can generally be separated into three categories (though some share categories): Increased thermogenic effect – this refers to increased heat production, metabolic rate and fat oxidation; Reduced nutrient absorption – when fat or carbohydrate calories are absorbed less efficiently; Decreased appetite – some nutrients and ingredients may decrease hunger, making it easier to reduce energy intake.
Best Appetite Suppressants
Lean Bean is our number 1 pick and the ideal appetite suppressant. It’s well-known by females throughout the athletic industry. This capsule was recently reformulated with all-natural ingredients and no stimulants that can be harmful to your body. If you have goals to reach but have found yourself fighting to shake some of that fat holding you back, this is the supplement for you.
This appetite suppressant from Lean Bean is designed to be taken routinely with high dosage that is hard to beat. You can expect consistent and constant results if you take the dosages as recommended.
Not only does Lean Bean act as a dietary supplement for appetite suppressant but you can also expect to feel higher energy and better focus leading you to having an overall better health as well as feeling those athletic body changes you are striving for.
2Powher Cut Blend
Powher’s cut blend was specifically designed to work on its own, regardless of diet and exercise routines. Obviously, your best results will still show with a change in lifestyle but this formula is designed with natural ingredients that work hard for you.
This is a simple system that recommends taking a dosage before breakfast, lunch, and dinner. Your cravings will be greatly reduced. The difference between Powher and many other dietary supplements is that Powher is created with the appropriate dosage and ingredients for maximum effectiveness.
PhenQ combines 5 separate philosophies to fully target and effectively lose weight. PhenQ’s formula works to burn fat, reduce your body’s production of fat, suppress your appetite, boost your energy, and improve your moods. Losing weight is a challenge and it can often leave you feeling unsatisfied, grouchy, and irritable with slow results.
Thanks to the compound from PhenQ, you only have to take 1 pill to resolve each of these issues. This product is formulated with FDA and GMP approved ingredients to ensure you are putting wholesome items into your body.
4Legion Athletics Phoenix
If you’re tired of appetite suppressants that are packed with caffeine this may be a more suitable option for you. Legion Athletics Phoenix is caffeine-free but works to boost your metabolism, burning that stubborn fat off of your body.
Legion Athletics is very straightforward with factual information and realistic views of what you can expect for weight loss. This supplement is meant to work alongside a healthy diet and exercise routines.
The compounds used in Phoenix help to aid you in losing an extra ½ pound per week on top of your weight loss with traditional efforts. This is an acceleration of up to 50%.
5Genius Diet Pills
The Genius Brand created a profound dietary supplement with their Genius Diet Pills. These appetite suppressant pills are safe and natural for both men and women. Take your weight loss to the next level with these veggie capsules. Additionally, these saffron supplements can manage cortisol levels and support your thyroid for ultimate health overall.
The key purpose of this supplement is to help regulate and to be highly efficient while helping you develop a routine that leads to weight loss and improved health concepts.
6Pure Sciences Appetite Suppressant
Pure Sciences has delivered an ideal system with these appetite suppressant drops. This bottle holds a 60-day dosage well past the typical 30 you get with most products. This appetite suppressant is made with all-natural ingredients and is made directly in the USA.
Pure Sciences formula has many benefits such as lower cholesterol, faster fat loss, appetite suppressant, reduce blood sugar levels, boost metabolism, and cleanse. The drops are designed to be taken a few minutes before you eat each meal and will help you better control your portions so that you are not tempted to overeat.
7Orphic Nutrition 100% Pure Garcinia Cambodia Extract
Orphic Nutrition’s Garcinia Cambodia extract appetite suppressant has 2100 mg per serving which is more than double traditional supplements.
This formula has no extra fillers and is formulated to be vegan and vegetarian friendly. This is a GMP certified compound that blocks carbs and will give you that breakthrough you’re looking for to eliminate fat and proceed with your weight loss goals. The blend is 3rd party tested and will help you produce maximum results.
8AtraFen Elite Professional Formula
AtraFen Elite is a perfect solution appetite suppressant for anyone and is formulated to also work great for individuals on the keto diet. This compound is made in the USA and is the company is registered with the FDA as well as GMP. You can expect to experience reduced cravings, improved metabolism, and renewed focus and energy.
The formula of AtraFen elite is designed to take your weight loss results to the next level by working in conjunction with your healthy diet and exercise routine.
9Burn-XT Thermogenic Fat Burner
The Burn-XT Thermogenic fat burner is designed with natural vegetables formulated together to create a fat-burning capsule that helps to suppress your appetite, lose weight, and boost energy.
This fat burning formula is made in a cGMP manufacturer within the USA. The products within the compound are natural and of the highest quality to provide an ultimate thermogenic formula that is effective for both men and women.
10Meal Enders Cravings Control Lozenges
Meal Enders takes a different approach to appetite suppression. Meal Enders are candy used to curb excess snacking or overindulgence at mealtime. It rewards and resets the taste buds with the sweetness of the chocolate and mocha outer layer, followed by a refreshing palate cleanse from the long-lasting center.
Meal Enders help to promote mindful eating, a positive relationship with food, and long-term healthy habits. MealEnders contain no weight loss drugs or stimulants, are gluten free, and have no artificial sweeteners.
How We Rank
The first thing that we reviewed for each supplement was the ingredient list. Taking a supplement that is compounded with terrible ingredients would be no good, despite the results they promise. We specifically looked for natural ingredients that did not contain fillers or additional items. Products that had bitter orange, ephedrine, sibutramine, or fenproporex were eliminated from review. These ingredients have life-threatening side effects on your health.
Rather we looked for ingredients such as Garcinia Cambodia, hoodia gordonii, caralluma, caffeine and other supplements that are natural and tend to have more minimal side effects. Products like Genius Diet Pills ranked higher because they included the neurotransmitter 5-HTP, which showed us that these brands are aware of the many pathways that appetite suppression can occur (not just increasing adrenaline).
Next we looked for unique appetite suppressants that went the extra mile. For example, Powher is a very potent combination and can work apart from other functions. Lean Bean was formulated specifically for women and contains ingredients and a compound that is designed to aid women with athletic performance and weight loss. AtraFen Elite was composed to be compatible with the keto diet but can be used by anyone.
Lastly we looked at promises and marketing. Did the companies promise unrealistic results or were they straight forward about what to expect and what changes you might need to make to see anticipated results?
For example, Legion Athletics Phoenix heavily discloses there is no magic pill and the supplement is meant to be an aid. Many appetite suppressants recommend a modified diet and exercise routine in order to see extensive benefits. What we were looking for was full disclosure as well as tested and shared results and reviews on the product.
After taking all those facts in, we came up with out top 10 best appetite suppressants.
1Appetite suppressants help control hunger. Appetite suppressants either indirectly or directly alter brain chemistry so that you feel satiated for longer periods of time when compared to other foods. And when you eat less you can achieve your calorie deficit much easier.
Natural appetite suppressants have been around for hundreds of years. Herbal laxatives have been used in Ayurvedic medicine for centuries, and even the Greek physician Soranus of Ephesus was said to have introduced various elixirs to stop his patients from overeating.
Some of these natural nutrients are said to help weight loss by boosting satiety and reducing feelings of hunger, without a stimulatory effect.
Common natural suppressants include:
- glucomannan – a fiber that shows inconsistent results for weight loss and appetite control (1)
- hoodia gordonii – high doses have been found to result in weight loss and appetite suppression but with significant side effects (2)
- chromium – studies don’t find it effective by itself (3)
- forskolin – some research to support its use in men (4)
- gallic acid – research hasn’t found this effective (5)
- green tea and ECGC – a review of 14 studies show only insignificant weight loss (6)
- capsaicin – research appears promising for appetite suppression use (7)
- Blends of the above ingredients are also used (8)(9)(10)
Currently, commercially-available appetite suppressants are a huge market in the weight loss industry. Although they’ve been used in traditional medicine for many years, the supplement industry continues to use these more and more.
To date, an ever-increasing number of appetite suppressant remedies are being manufactured. Some use the same kinds of herbal nutrients or foods, while others introduce less well-known blends of ingredients.
Prescription drugs can also act as appetite suppressants. When more modern appetite suppressant medicine came along in the early nineteen hundreds, drugs such as amphetamines became popular – along with prescription appetite suppressant drugs much later on that decade (11) (12).
The most common prescription appetite suppressants include (13):
- Bupropion-naltrexone (brand name: Contrave) – this is a combination drug of an anti-depressant and a drug used to treat opioid dependence.
- Liraglutide (brand name: Saxenda) – an injection medication that reduces GLP-1 (glucagon-like peptide-1), a substance that can increase insulin and lower blood sugar.
- Lorcaserin (brand name: Belviq) – a drug that modifies serotonin action
- Orlistat (brand name: Xenical) – a drug that reduces absorption of fat. This must be combined with a low fat diet to reduce risks of excessive loose stools.
- Phentermine-topiramate (brand name: Qsymia) – a combination drug of a stimulant and an anti-convulsant.
- Phentermine – acts like a stimulant, approved for short-term use only
- Mazindol – acts like a stimulant, approved for short-term use only
- Amfepramone (also known as diethylpropion) – a stimulant drug that raises levels of dopamine, norepinephrine
2Appetite suppressants may increase the satiety response. Some appetite suppressants decrease hunger signals, increase feelings of satiety, delay digestion or reduce absorption and ultimately, result in less calories you consume. Glucomannan is an example of a fiber that is used as an appetite suppressant because it extends satiety, takes up space in the stomach and delays emptying, though research to support its use for weight loss is inconclusive (14). Presuming you burn more than you eat, weight loss is more likely.
Appetite is controlled by a region of your brain called the hypothalamus (15).
As the master computer of the body, it is responsible for telling you exactly when you need food. A cascade of hormone changes lead you to feelhungry so you can find food. Being able to ‘forage’ an energy source is an important aspect of energy homeostasis and survival.
The hypothalamus helps us maintain body weight around a set point, and avoid all of the pitfalls that comes with low energy intake (malnourishment, illness, death).
However, with so much food available in the modern climate, many people take foraging to the extreme, overeating an abundance of calories, leading to weight gain. Combined with the many other factors that drive obesity, appetite suppressants have become a more common treatment for obesity.
3Appetite suppressants act on hunger hormones and neurotransmitters Appetite refers to the desire for food intake. Hunger itself relies on complex interaction between the central nervous system, hormones and the gut.
The hypothalamus controls hunger and satiety using hormones. The most important and relevant ones are leptin, ghrelin, CKK, PYY and GLP-1.
Appetite suppressants are said to improve weight loss by changing the way in which these hormones work. Some also act on noradrenergic and dopaminergic receptors (alongside hormones) to produce satiety (16).
They essentially hijack satiety and appetite hormones and interrupt the hunger signals when you should normally feel hungry, helping you reduce overall food intake.
4Research shows that prescription appetite suppressants can increase weight loss. There has previously been research showing appetite suppressant drugs can lead to significant weight loss by decreasing overall energy intake or by increasing energy expenditure.
For example, a study in the Lancet (17) found that a type of monoamine-reuptake (MOA) inhibitor manufactured as an appetite suppressant resulted in an average of 4-5 kg of weight loss when used long term. Few prescription appetite-suppressants are considered safe for long-term use.
One report suggested that weight loss was greater with appetite suppressants when compared to placebo (18). It also stated that net weight loss varied from 2 kg to 10 kg and this could be sustained for up to 36 months (as long as the drug was continued).
MOA reuptake inhibitors are said to cause weight loss by selectively uptaking neurotransmitters such as 5-HT, noradrenaline and dopamine. This in turn directly enhances appetite suppressing effects on the central nervous system and the associated hormones (19).
5Appetite suppressants might also burn more calories. Some appetite controlling drugs may also have an effect on total daily energy expenditure.
The now banned appetite suppressant sibutramine (20) was said to be able to prevent the drop in basal metabolic rate that is often seen during weight loss.
It did this by activating a protein involved in eating behaviour called MCR-4 (21).
Some tentative evidence also suggested that sibutramine also increased thermogenesis too (22).
According to some reports, “when used appropriately, appetite suppressants can be of real therapeutic benefit” (23).
6Natural hunger suppressants are often added to over-the-counter products, but may not be as effective. Appetite suppressing nutrients are often added to ‘fat burner’ supplements.
Natural ingredients such as caffeine, capsicum, ginger, piperine, glucomannan and grapefruit are often added to pharmaceutical supplements as a way of boosting satiety.
There are some clinical trials that have reported benefits of these nutrients.
For example, one study found that capsaicin offered modest improvements to both satiety and food intake choices in 24 men and women (24).
Specifically, ingesting capsules containing 0.9 g of red pepper (0.25 g capsaicin) increased satiety ratings from 689 to 757 mmh in the men and from 712 to 806 mmh in the women, both.
And in another study, ginger was found to reduce feelings of hunger too (25).
It’s worth noting though that the research on natural appetite suppressants isn’t unequivocal.
For example, a study published in the European Journal of Nutrition (26) found that adding the compound capsaicin to meals did not increase satiety, energy expenditure or had any effect on hunger hormones.
Likewise, a clinical study analyzing the safety and efficacy of glucomannan found that even though it is added to fat burner supplements as an appetite suppressant, it did not significantly alter body composition, hunger/fullness, or lipid and glucose parameters (27).
7Appetite suppressants can provide mental clarity. One of the most common qualities of appetite suppressants is that they often do much more than just help control your appetite and cravings.
Appetite suppressants can also provide mental clarity and focus that will push you towards your goal while positively affecting your moods and helping to prevent those mood swings that commonly accompany dieting. While your body is adjusting to your dietary changes, these supplements can help you overcome hurdles (28).
Appetite suppressants have been implicated in a number issues, including side effects and adverse reactions.
1Appetite suppressants can cause mild to moderate IBS like effects. These include: nausea, sickness, gastrointestinal discomfort, blurred vision, sleeplessness, insomnia and lack of energy, constipation, diarrhea and trouble urinating, dry mouth, irritability, elevated heart rate, mood changes and breathing difficulties.
There have also been cases of more severe adverse reactions reported too.
2Appetite suppressants can increase the risk of primary pulmonary hypertension. A prospective case-controlled study found that there was a clear and significant correlation between appetite suppressant, ‘anorexia drug’ fenfluramine and pulmonary hypertension (29).
The odds of suffering from this serious medical condition were said to be more than double when taken for over three months. This resulted in the removal from the market of this drug in 1997.
3Prescription appetite suppressants increase risk of cardiac valve disorders. Both fenfluramine and phentermine have at one time or another been implicated in higher risk stratification for cardiac valve disorders – in particular aortic and mitral valve insufficiency.
One study reported that pharmacological effects of these drugs elevated the risk of these cardiac-based illnesses (30).
The results showed that in those who had taken either fenfluramine and phentermine for four or more months, the cumulative incidence of idiopathic cardiac-valve disorders was 35.0 per 10,000 subjects. Zero reports of this condition were found among those who had not taken either drug.
And in a case study of a 28-year old male, an over-the-counter MAO inhibitor was seen to cause ‘hypertensive crisis’ after ingestion (31).
4Commercial diet pills containing appetite suppressant ingredients can increase blood pressure. One case study found that a patient presented to the ER after ingesting commercially available diet pills containing the appetite suppressant phenylpropanolamine. The inhibition of prostaglandins (chemicals that have hormone-like effects in the body) caused by the drug resulted in extreme hypertension (32).
5Appetite suppressants have certain drug interactions. Oral appetite suppressants can interact with some prescribed medications such as MAO inhibitors (linezolid and furazolidione in particular).
They can also interact with other types of weight loss medicines, as well as supplements.
Because the term ‘appetite suppressant’ covers a group of drugs and supplements rather than one individual product there is no clear, catch-all dosage. For prescription drugs, dosage instructions range from 8-50 mg once daily to begin with.
Recommendations may include scaling up dosage over time, up to three times per day once initial safety has been established.At no point are prescription appetite suppressants recommended to be taken at doses above 250 mg per day or for an indefinite period of time.
For natural compounds, dosage also varies. For example, capsaicin is often recommended to be effective at 150 mg in healthy adults, and glucomannan at around 2g per day. Clinically effective doses of synephrine range from 25 to 50 mg. Studies show naringenin is effective at 600 milligrams when used in conjunction with synephrine and hesperidin.
The clinically effective dose of EGCG ranges between 50 and 1,000 mg. While scientists haven’t pinned down an exact dose yet, 25 to 50 milligrams forskolin is known to be effective. 5-HTP seems to be effective between 150-500mg. The clinically effective dose of caffeine is between 3 and 6 milligrams per killogram of body weight. Yohimbine, is much lower, having an effective dose between 0.1 and 0.2 milligrams per kilogram of body weight.
The maximum recommended dosage of Garcinia Cambogia 2.8g/day. The ideal dose has not been identified but the higher the dose, the more common the side effects. After 2800mg, it seems side effects are increased. Top Garcinia Cambogia supplements should contain at least 50-60% HCA to ensure proper absorption and function of HCA in your body.
For the more obscure and less-studied supplements, simply follow the guidelines on the supplement bottle.
Is nicotine an appetite suppressant? Yes, and its a big reason smokers are often not overweight.
Can you shrink your stomach to control appetite? Your stomach remains the same physical size once you become an adult — unless you have surgery to intentionally make it smaller. However, portion control, increased fiber intake and other changes can you help you feel more full and satisfied with less quantity of food and/or calories.
Do appetite suppressant pills really work? It depends. Someappetite suppressant pills with proper dosages and ingredients may curb hunger in the short-term, others show no effect.
Can I take multiple appetite suppressants? You can rotate various appetite suppressants but you should not take more than one appetite suppressant at one time. Many appetite suppressants are formulated with similar ingredients. If you use more than 1 supplement with the same ingredients it will not make your results better but rather could overdose your system with the ingredients of the supplements. Your goal is to make your body healthier and aid in weight loss, but remember that even the healthiest and natural ingredients can be taken in quantities that are too much. Take care of your overall health and use only 1 supplement at a time with the recommended dosage applied. If you tire of one or feel as though it is not delivering the results you desire, try changing to a new product but do not use them simultaneously.
Are there natural appetite surpresssing foods? Yes, there are. Spinach is a source of thylakoids, which have been associated with levels of leptin, the hormone that signals you to “stop” eating. Many foods are also rich in fiber that act as natural appetite suppressants.. Examples include: cruciferous vegetables, artichokes, berries, apples, beans, lentils, almonds, pistachios, and some whole grains. Fiber can keep us satisfied and full, while contributing minimal calories.
Do appetite suppressant patches work? There is not enough scientific evidence to prove appetite suppressant patches do work.
Do appetite suppressants have caffeine? Some appetite suppressants have caffeine in them. It is important to check the ingredient list and familiarize yourself with what is included in the supplement you choose to try. The suppressants that contain caffeine recognize that there are various reasons to be taking the supplement and typically are striving to help you not feel like you need to reach for a soft drink and to give you higher energy levels to make it through your day. If you particularly want a suppressant that does not contain caffeine, pay special attention to the ingredients looking for one that advertises caffeine-free or does not contain caffeine in the ingredient list.
Are appetite suppressants dangerous? Yes, some may result in major health effects, even when used according to the dosage guidelines.
Can I take appetite suppressants while breastfeeding? Taking appetite suppressants while breastfeeding is an ill-advised way to lose baby weight. While you’re breastfeeding, your need for calories and nutrients also increases so you can give your body — and your baby — adequate daily nutrition.
Is there a time limit to taking appetite suppressants? Some appetite suppressants are meant to be cycled out of your routine while others are designed so that you could use for the remainder of your life if you felt that was what would work best for you. The purpose of an appetite suppressant is to help you train your body to fight cravings and not feel the need to snack excessively or overeat at meals. Some appetite suppressants carry side effects with them as well. In general, you should plan to only use an appetite suppressant for about 8-12 weeks at one time. Then cycle off of the suppressants and test your body and your mind. Once you have allowed your body to reset for a few weeks, you can continue using appetite suppressants again. If you are able to discontinue using appetite suppressants and not begin gaining weight again, we recommend that you not begin taking them again unless you feel they are needed?
What drug suppresses the appetite? The FDA has approved these medications that you can only get with a doctor’s prescription: Liraglutide (Saxenda).
Does apple cider vinegar help with weight loss? According to this study, adding 1 or 2 tablespoons of apple cider vinegar to your diet can help you lose weight. It can also reduce your body fat percentage, make you lose belly fat and decrease your blood triglycerides.
Do you need a prescription for appetite suppressants? There are appetite suppressants that require a prescription from a medical professional. Some examples of these are Phentermine, Contrave, and Orlistat (Xenical) are some popular examples of prescription weight loss supplements. However, there are numerous options that do not require prescriptions to purchase. The majority of appetite suppressants are available over the counter for your convenience because they contain natural ingredients with proven benefits rather than some of the highly potent ingredients prescriptions carry. Each of the products shared in our ranking can be purchased and used without a prescription.
Appetite suppressants claim to help with weight loss by reducing hunger and increasing satiety.
They may also have a direct effect on weight loss in some cases by increasing thermogenesis and offsetting a drop in metabolic rate while dieting. Weight regain often occurs once the product is stopped.
Research indicates that prescription appetite suppressants may help with weight loss. However, the number of case reports detailing adverse reactions and mild to serious side effects is concerning. Studies with follow-up find weight loss is not usually maintained once the drug is discontinued.
There have been a number of attempts to make a prescription appetite suppressant that is free from or causes only minor side effects. Unfortunately, manufacturers have failed so far.
Natural herbs, foods and nutrients have been shown to enhance weight loss in some studies, however the results rarely consistent.