Wrinkle creams are popular over the counter products found in your local pharmacy or drugstore designed to help fight off premature aging, restore youth, and prevent future damage or wrinkles.
The compounds found inside many popular wrinkle creams have anti-inflammatory, antioxidative, and protective effects on the skin, with some studies narrowing in on possible anti-cancer and wrinkle reduction properties.
Best Wrinkle Cream
1. Neutrogena Rapid Wrinkle Repair Moisturizer with Sunscreen
Neutrogena Rapid Wrinkle Repair has been clinically tested and visibly reduces the appearance of wrinkles and fine lines, including crow’s feet and forehead lines. Retinol renews skin and reduces age spots and discoloration. The glucose complex accelerates the activity on the surface of your skin to achieve rapid results.
The hyaluronic acid in this product can hold up to 1,000 times its weight in water, so it quenches dry skin and offers incredible moisture while remaining lightweight and absorbing quickly without clogging pores. Neutrogena Rapid Wrinkle Repair has everything it needs to make a great wrinkle cream, which is why it’s our #1 ranked product.
2. Kleem Organics Advanced Retinol Moisturizer Age Defying Solution
Kleem Organics Advanced Retinol Moisturizer is vegan and contains no parabens, phthalates, mineral oils, or synthetic fragrances. It is also gluten-free and does not use animal testing. It’s free of alcohol and non-acnegenic and non-comedogenic, so it is suitable for all skin types, even sensitive skin.
This anti-aging face cream uses retinol along with hyaluronic acid, vitamin C, vitamin E, green tea, and jojoba for deep hydration that lasts for up to 72 hours. Kleem Organics products are manufactured in the USA in a facility that was approved by the FDA and endorsed by PETA as certified cruelty-free.
3. InstaNatural Vitamin C Moisturizer
InstaNatural Vitamin C Moisturizer uses aloe vera, niacinamide, hyaluronic acid, and sunflower seed oil to correct wrinkles and hyperpigmentation.
The serum is made with no parabens, mineral oil, SLS, SLES, formaldehyde or ingredients that release formaldehyde, petroleum, polyethylene glycol (PEG), DEA, MEA, TEA, and no unsafe preservatives. InstaNatural Vitamin C Moisturizer is made in the USA using materials and never tested on animals.
4. LilyAna Naturals Retinol Cream Moisturizer
LilyAna Naturals cream uses an advanced formula to combat aging that can be used daily and nightly. It contains organic ingredients including hyaluronic acid, vitamin E, green tea, shea butter, and jojoba oil.
It also contains no artificial fragrances or parabens and is gluten-free and cruelty-free.
5. L’Oreal Paris Collagen Moisture Filler for Day and Night
L’Oreal Paris Collagen Moisture Filler For Day And Night is lightweight and does not leave grease on your skin It provides deep hydration and moisturizes any skin type.
This product reduces lines and wrinkles, offering glowing and radiant skin. It is non-comedogenic and has been tested for safety by dermatologists.
6. Baebody Beauty Retinol Ultimate Moisturizer Cream
Baebody Beauty Retinol Ultimate Moisturizer Cream combines retinol with shea butter, vitamin E, vitamin B5, jojoba oil, and green tea to fight the appearance of fine lines and wrinkles while moisturizing your face.
It’s made in the USA and is never tested in animals.
7. Tree of Life Age Defying Beauty Retinol Serum for Face and Skin
Tree of Life Age Defying Beauty Retinol Serum for Face and Skin is made in the USA. It is cruelty-free and never tested on animals. It is 72% organic and safe for all skin types.
The Tree of Life Age Defying Beauty Retinol Serum for Face and Skin is 98% natural and 72% organic. It is soft and moisturizes while targeting fine lines and age spots.
8. Medix Retinol + Ferulic Acid Anti Sagging Treatment
Medix Retinol + Ferulic Acid Anti Sagging Treatment treats wrinkles with black tea, aloe vera, and chamomile.
It’s vegan, never tested on animals, free of parabens, alcohol-free, and contains no PEGs, formaldehyde, sulfates, dyes, triclosan, propylene glycol, mineral oil, or talc.
9. Cosmedica Skincare Pure Hyaluronic Acid Serum
Cosmedica Skincare Pure Hyaluronic Acid Serum is made from the purest form of hyaluronic acid, offering intense moisture treatment for your skin to guard against aging and wrinkles.
This serum is free of any parabens and offers a professional-grade formula that is free of any grease and oil. It’s also vegan and free of any cruelty.
10. Eucerin Q10 Anti-Wrinkle Face Cream
Eucerin Q10 Anti-Wrinkle Face Cream is fragrance-free, alcohol-free, and non-comedogenic, using vitamin E and beta-carotene to enrich the skin’s natural beauty.
Q10 is a coenzyme that occurs naturally inside your body. It defends your skin against the process of aging. The older you get, the lower your Q10 content becomes, so this moisturizer includes Q10 to replenish your body’s supply and help defend against wrinkles and signs of aging.
How We Rank
The first thing we looked at when formulating our rankings for the best wrinkle creams, was third party testing, purity, and clinical trials. All our products, like Kleem Organics and Baebody Beauty, are manufactured in the USA, which has more rigorous standards. This means that all of these products are safe for consumption.
We next looked at the ingredients. We preferred active ingredients that were clinically tested, to guarantee their effectiveness. Retinol has been studied extensively and is the active ingredient in some of our top-ranked products, like Neutrogena Rapid Wrinkle Repair. Another part of analyzing ingredients is ensuring they are all-natural. Most products on our list are vegan and are organic. This means that you won’t be putting parabens and other toxins in your system.
Finally, we made sure that these products were cruelty-free. Ethics in skincare is very important. Products that made our rankings, like LilyAna Naturals and Cosmedica, are never tested on animals. They are made from global ingredients that are ethically sourced through sustainable means.
1. Vitamin A acts as a powerful antioxidant, protecting the skin from free radicals and preventing skin damage or wrinkles. Retinol is found on many wrinkle cream ingredient lists. It’s essentially composed of Vitamin.
A 2007 study sought out to evaluate the benefits and effectiveness of topical retinol on naturally aged skin. 36 elderly participants with an average age of 87 years old were involved in the study. The lotion used contained 0.4% retinol. It was applied 3 times a week to each participant for 24 weeks.
Skin biopsies were used as the main mode for measurement and evaluation. The results showed a substantial difference improvement in fine wrinkle scores for the treated skin. Researchers concluded that this was likely due to water retention as well as increased collagen production. The skin was able to withstand damage or injury in the future (1).
Another study published in Cancer Epidemiology Biomarkers and Prevention showed retinol reduces incidences of certain skin cancers by preventing damage to the skin and its structure. Researchers concluded that retinol could potentially aid in preventing squamous cell carcinoma. However, they also reported that it was not effective in preventing and reducing the risk of basal cell carcinoma (2).
A 2009 study published in the Journal of Dermatology further evaluated the effectiveness of retinol at reducing wrinkles and preventing them. 30 Japanese women with wrinkles in the corners of their eyes participated in this specific study. The lotion containing retinol was applied to one side of their face for 8 weeks. The retinol lotion moderately improved wrinkles in 34% of subjects. Researchers also noted that it was well-tolerated and no participant experienced significant side effects (3).
Another study in the Journal of Investigative Dermatology Symposium found that retinol caused the growth of keratinocytes and fibroblasts, as well as strengthened the extracellular matrix of the skin, demonstrating its protective effects (4).
2. Vitamin C acts as an antioxidant, preventing sun damage to the skin. A common ingredient, Vitamin C, in wrinkle cream products provides another protective compound. In a study published in the British Journal of Dermatology, researchers explored Vitamin C and its effect on sun-damaged skin.
The study showed that Vitamin C levels actually become depleted with sun exposure. This leaves the skin susceptible to damage. Researchers suggested that Vitamin C supplementation or topical application may prevent this damage from occurring (5).
A 2003 study observed the use of Vitamin C and E in UV photo-protection. A solution containing these two vitamins was applied to pig skin daily for 4 days consecutively. Researchers discovered that this application yielded antioxidative protective properties and suggested that these two vitamins can be used to protect the skin from the sun and prevent skin cancer, as well as photoaging (6).
Another study supported the use of topical Vitamin C for skin protection. In this particular study, researchers observed Vitamin C and its effectiveness in skin protection via oral supplementation. But it was found that this type of administration had no real effect on oxidative stress in the skin (7).
3. Hydroxy acids act as an exfoliant, removing dead skin cells, as well as stimulating the growth of new skin cells. A study in the Journal of the American Academy of Dermatology looked at the use of hydroxy acids in improving photoaged skin.
Participants applied a lotion for 6 months that contained 25% glycolic, lactic, or citric acid. The results showed a surprising 25% increase in skin thickness, improved elastic fiber quality, and increased collagen. Conclusively, researchers determined that hydroxy acids did improve photoaging (8).
Another study also evaluated the use of hydroxy acids in treating photodamaged skin. 74 women participated in the study, aging from 40-70 years of age. Each participant had moderate to severely photodamaged skin. The study concluded by saying that topical 8% glycolic acid and 8% L-lactic acid creams were useful when it came to treating photodamaged skin. These researchers also noted that such creams were tolerated well by the study’s participants (9).
In another study, skin peels involving hydroxy were examined in conjunction with an improvement in photoaged skin. These results showed mild improvements in the skin of the 44 participants. These improvements included decreased roughness, reduced fine wrinkles, and epidermal thickening (10).
4. Coenzyme Q10 is often included in wrinkle cream products to reduce fine wrinkles around the eyes, as well as protect the skin from UV light damage. It is thought coenzyme Q10 does this via antioxidant properties as demonstrated in several studies (11).
One scientific article described coenzyme Q10 and its effects on the skin. The authors determined that topical application of this specific ingredient improves mitochondrial function in the skin; thus improving overall skin health (12).
In one study, researchers investigated coenzyme Q10 in topical applications and their role in preventing photoaging. It was found coenzyme Q10 reduced oxidation and wrinkle depth. Ultimately, it showed that coenzyme Q10 could prevent photoaging (13).
Another 2009 study also demonstrated similar results. Researchers examined coenzyme Q10 in human dermal and epidermal cells. The study showed that coenzyme Q10 had protective effects involving preventing cell death and preventing oxidative stress (14).
5. Peptides are another ingredient used in wrinkle cream products to promote wound healing, reduce stretch marks, and prevent wrinkles. Peptides have growth factors that promote proper and effective healing of a wound on the skin. They have been used in a variety of ways to speed up the healing process and enhance it (15).
A 2004 study found that collagen-like peptides can have a significant antiwrinkle effect on the skin when applied topically. The study looked at 20 healthy female volunteers aged 40 to 62 and found consistent improvement in 75 to 80% of the tests (16).
Another study showed peptides could potentially prevent and reduce wrinkles. 20 participants took part in the study. The topical lotion was applied around the eye area 2 times a day for 4 weeks. It was found that wrinkles were significantly reduced, including the number of wrinkles and their depth (17).
6. Tea extracts can be found in wrinkle cream products which further the antioxidant effects of the product. In a 2013 study published in the Journal of Cosmetic Dermatology, researchers explored the use of green tea extract in preventing wrinkles. The lotion was applied for 8 weeks to the participant’s crow’s feet around their eyes.
Most participants reported moderate improvement in their wrinkles, giving way to researchers to infer that green tea extract does have antioxidant activity that can aid in preventing and reducing wrinkles (18).
Green tea extract was also observed for the use of reducing and improving photodamage. This particular study was conducted on mice. It was found that the lotion containing green tea extract was more effective in protecting the skin from UVB photodamage when compared to the control group (19).
7. Grape seed extract promotes antioxidant effects, anti-inflammatory effects, and wound healing. One study showed that grape seed extract was numerous times more effective than the commonly used Vitamin E (20).
1. Retinol may cause redness, dryness, irritation, sensitivity to sunlight, redness, other skin discoloration, crusting, swelling, or blistering. It is always best when trying out a new product to try a small dime-sized amount on your wrist or forearm before applying it to your entire facial area (21).
2. Hydroxy acids may cause similar reactions to retinol. Proceed with similar caution. If you already have sensitive skin, hydroxy acids may cause increased irritation and aggravation.
3. Coenzyme Q10 may cause some people to break out in allergic rashes. It is also cautioned to discontinue the use of coenzyme Q10 at least 2 weeks before surgery. Always perform a skin test with a new product before using it.
4. Pregnant women may need to avoid wrinkle products. As with anything when pregnant, always consult with your doctor to ensure that it is safe to apply certain products and their ingredients to your skin.
There is no standard dosage for wrinkle creams as every product is different and every skin is slightly different.
Many users find benefits to applying wrinkle creams in the morning and at night but always perform a skin test to ensure that you don’t have a negative reaction to any product.
Do creams really help wrinkles? The effectiveness of anti-wrinkle creams depends in part on the active ingredient or ingredients. Many of the active ingredients found in wrinkle cream products have been shown to improve wrinkles.
What age should you start using anti-wrinkle cream? From the age of 25-30, you should start to give your skin the protection it needs. UV filters and adapted anti-aging ingredients, such as creatine and hyaluronic acid, are essential to protect your skin as you age. Skin type and age play an important role in choosing the best face cream.
Does lemon juice help wrinkles? Yes, lemon juice can help wrinkles. Rid your face of dead skin cells by making a lemon juice mixture and applying it daily. The acid in the lemon juice will help to tighten up your skin, which can help eliminate the wrinkles that are caused by age.
Are anti-aging creams safe? Anti-aging products typically contain hydroxy acids to increase the permeability of the skin and allow anti-aging ingredients to pass through. For the most part, dermatologists hold that good skincare habits are a safe and effective alternative to investing in anti-aging creams.
Does coconut oil help with wrinkles? Coconut oil is an excellent massage oil for your skin and may be used as an effective moisturizer for all skin types. It may be massaged into the skin each night before bed to help reduce the appearance of fine lines and wrinkles and to reduce premature aging.
Does Preparation H work on wrinkles? Preparation H has long been known as an effective treatment for those who suffer from painful hemorrhoids, but it also has a more unusual use in some skincare circles, as it has been found that using Preparation H for wrinkles works to lessen the appearances of eye bags and other fine lines and wrinkles around the eyes.
Does coconut oil get rid of wrinkles? Yes, coconut oil can help get rid of wrinkles. It may be massaged into the skin each night before bed to help reduce the appearance of fine lines and wrinkles and to reduce premature aging. There’s some evidence that coconut oil may help treat dermatitis better than other oils.
Is there a cure for wrinkles? The only FDA-approved topical treatment for wrinkles is tretinoin, known commercially as Retin A. Ashinoff says this prescription cream reduces fine lines and large wrinkles and repairs sun damage.
What foods slow down aging? The best foods for slowing down aging are high in antioxidants. This includes foods such as olive oil, yogurt, dark chocolate, nuts, berries, fish and red wine.
Does apple cider vinegar help wrinkles? Yes, the vinegar acts as a toner; keeping skin cells hydrated which prevents wrinkles as well.
What is the best treatment for deep wrinkles? Retinoids are your best option when combatting deep wrinkles. Derived from vitamin A, retinoids — such as tretinoin (Renova, Retin-A) and tazarotene (Avage, Tazorac) — that you apply to your skin may reduce fine wrinkles, splotches, and skin roughness.
What home remedy can I use to look younger? Mix 2 tbsp pure coffee powder sans chicory with 2 tbsp unsweetened cocoa powder, 1 tsp honey, and a few drops of milk and coconut oil to prepare a paste. Apply this on your face and wash off after 20 minutes to reveal an energized, younger-looking skin. Use lemon juice in place of honey if your skin is oily.
What is the best treatment for face wrinkles? Treatments available for skin wrinkles include topical medical treatments (such as vitamin A acid, alpha hydroxy acids, antioxidants, and moisturizer) and more invasive procedures (such as glycolic acid peels, deep peels, dermabrasion, laser resurfacing, surgical procedures, injection of fillers, and Botox).
Are wrinkles permanent? Wrinkles are a natural part of the aging process. As people get older, their skin gets thinner, drier, less elastic, and less able to protect itself from damage. This leads to wrinkles, creases, and lines on the skin. Environmental factors such as smoking can accelerate the development of wrinkles.
Does coconut oil tighten skin? It has become a familiar staple in many kitchens and can also be used to tighten your skin. Coconut oil is a powerful antioxidant that works to eliminate free radicals that can damage your skin. Also, coconut oil hydrates and moisturizes your skin, which prevents sagging.
Will wrinkle creams work the same as a facelift? Wrinkle cream won’t have the same effect as Botox or a facelift. But these products can help improve the vitality, health, and look of your skin. They further may prevent future damage caused by age and sun exposure.
Wrinkle cream has become very popular in today’s society as individuals seek out solutions to aging or damaged skin. Commonly used ingredients in wrinkle cream products include retinol, Vitamin C, coenzyme Q10, hydroxy acids, peptides, tea extracts, and grape seed extract. These products aim to reduce and prevent wrinkles, encourage antioxidant effects and anti-inflammatory effects, promote wound healing, and more.
Many of these ingredients were also well tolerated by participants throughout various studies, with few adverse side effects. Side effects primarily occur in those with sensitive skin or pre-existing conditions. When trying out a new product, make sure to first apply the wrinkle cream to the skin of your forearm or wrist and leave it for a few hours. If not adverse effects or irritation occurs, it is likely safe to apply to the face or other areas of the body.
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